Her film work includes the 2009 remake of 1987 thriller The Stepfather and the Brendan Fraser comedy Furry Vengeance (2010). On TV she appeared as succubus Andie Bates on the ABC supernatural crime drama "The Gates". At the 2011 Teen Choice awards, she was nominated as Breakout Star for her titular role in the ABC Family series "The Nine Lives of Chloe King". She has starred in the first season of new horror comedy series created by Ryan Murphy called Scream Queens as Grace Gardner.
Samuels is the daughter of Kathy, a producer for unscripted series, and Scott, a U.S. marshal. She has three brothers, Cody, Harrison, and Jack, and one sister, Heather.
- There is a possibility that Skyler was an uncredited extra in the final episode of Coven.
- Skyler starred in Season One of Ryan Murphy's Scream Queens in 2015.
- She is one of the five actors to work on both American Horror Story and Scream Queens. The others are Billie Lourd, Colton Haynes, Dalton E. Gray and Emma Roberts.