Bomer was born in Webster Groves, Greater St. Louis, Missouri. He attended Carnegie Mellon University in Pittsburgh, Pennsylvania. After graduation, he moved to New York where he starred in the soap opera All My Children.
Bomer starred in the hit tv show White Collar from 2009 - 2014.
In 2014 he joined the cast of American Horror Story and starred as Andy, a male prostitute who was having an affair with Dell Toledo. In 2015, he returned for the fifth season of American Horror Story as Donovan.
- While accepting the Steve Chase Humanitarian Award in 2012, Matt Bomer publicly acknowledged that he was gay for the first time.
- He is married to Simon Halls, his publicist. They married in 2011 and have three sons.
- Both characters played by Matt Bomer died in the season in which they appear.
- Ironically Andy was killed by Dandy (Finn Wittrock) in the fourth season, while Rudolph Valentino (Finn Wittrock) was killed by Donovan in the fifth one.